Epigenome-wide DNA methylation profiling of portal vein tumor thrombosis (PVTT) tissues in hepatocellular carcinoma patients
نویسندگان
چکیده
منابع مشابه
FDG-avid portal vein tumor thrombosis from hepatocellular carcinoma in contrast-enhanced FDG PET/CT
Objective(s): In this study, we aimed to describe the characteristics of portal vein tumor thrombosis (PVTT), complicating hepatocellular carcinoma (HCC) in contrast-enhanced FDG PET/CT scan. Methods: In this retrospective study, 9 HCC patients with FDG-avid PVTT were diagnosed by contrast-enhanced fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT), which is a comb...
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The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...
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Portal vein tumor thrombosis (PVTT) is a common paraneoplastic condition in advanced primary hepatocellular carcinoma or hepatobiliary tract malignancies. Tumors with PVTT are frequently associated with adverse and aggressive features such as intrahepatic tumor dissemination, early treatment failure, or deterioration of hepatic function. Therefore, the treatment outcomes for PVTT in historical ...
متن کاملfdg-avid portal vein tumor thrombosis from hepatocellular carcinoma in contrast-enhanced fdg pet/ct
objective(s): in this study, we aimed to describe the characteristics of portal vein tumor thrombosis (pvtt), complicating hepatocellular carcinoma (hcc) in contrast-enhanced fdg pet/ct scan. methods: in this retrospective study, 9 hcc patients with fdg-avid pvtt were diagnosed by contrast-enhanced fluorodeoxyglucose positron emission tomography/computed tomography (fdg pet/ct), which is a comb...
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We performed a retrospective review of 281 hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) treated with radiation therapy (RT) between 1998 and 2008 to develop a prognostic model for those patients. Of the 281 patients, PVTT and intrahepatic main masses completely disappeared in 10 patients (3.6%), and shown a partial response in 141 patients (50.2%). The median...
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ژورنال
عنوان ژورنال: Neoplasia
سال: 2020
ISSN: 1476-5586
DOI: 10.1016/j.neo.2020.09.007